| Potent inhibitor of protein phosphatases, especially the PP-1 and PP-2A classes, in numerous cell types. Okadaic acid is a widely distributed marine toxin produced by several phytoplanktonic species and responsible for diarrheic shellfish poisoning in humans. At the molecular level, Okadaic acid is a potent and specific inhibitor of various types of serine/threonine protein phosphatases. Due to this enzymatic inhibition, Okadaic acid was reported to induce numerous alterations in relevant cellular physiological processes, including metabolic pathways such as glucose uptake, lipolysis and glycolysis, heme metabolism and glycogen and protein synthesis. OA. EU regulated marine toxin. Synonyms: (2R)-3-[(2S,6R,8S,11R)-2-[(E,1R)-3-[(2S,2&primeR,4R,4aS,6R,8aR)-4-Hydroxy-2-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-3-methylene-spiro[4a,7,8,8a-tetrahydro-4H-pyrano[2,3-e]pyran-6,5-tetrahydrofuran]-2-yl]-1-methyl-prop-2-enyl]-11-hydroxy-4-methyl-1,7-dioxaspiro[5.5]undec-4-en-8-yl]-2-hydroxy-2-methyl-propanoic Acid, Spiro[furan-2(3H),2(3H)-pyrano[3,2-b]pyran], acanthifolicin deriv., 35-Demethyl-DTX 1, 35-Demethyldinophysistoxin 1, NSC 677083 CAS No: 78111-17-8 Molecular Formula: C44H68O13 Molecular Weight: 805.00 Appearance: White to off-white powder Purity: 98% Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Warnings: Highly irritant to skin and mucous membranes. Tumor promoter. Gloves and mask should be worn when using this compound. Care must be taken to prevent contact through all routes of exposure. |
