| The function of the delta-opioid receptors has not been determined. However, recent studies in rodents have linked delta-opioid receptor antagonists with prevention of morphine tolerance and dependence without relinquishing mu-opioid antinociception. In general, opioids modulate numerous central and peripheral processes, including pain perception, neuroendocrine secretion and the immune response. The opioid signal is transduced from receptors through G proteins to various different effectors. Subsequent to G protein activation, several effectors are known to orchestrate the opioid signal. For example, activation of opioid receptors increases phosphatidylinositol turnover, activates K+ channels and reduces adenylyl cyclase and Ca++ channel activities. Amino Acid Sequence (360-372): NH2-Cys-Thr-Pro-Ser-Asp-Gly-Pro-Gly-Gly-Gly-Ala-Ala-Ala-COOH Molecular Weight: 1060.1 Control Peptide for Opioid Receptor, delta, CT, aa360-372 Pab Rb x Hu Catalog No: O7030-10 and O7030-11. |
