Peroxiredoxin 2, also known as PRDX2, is a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. Peroxiredoxin 2 may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. If Peroxiredoxin 2 protection is inadequate against peroxidases, the resulting protein and DNA damage may result in neurological disease such as Alzheimers or DNA damage leading to cancer. Source: Recombinant human Peroxiredoxin 2 protein was expressed in E.coli. Molecular Weight: 21.8kD (198aa) Biological Activity: Specific activity is 200-230 pmole/min/ug, and was obtained by measuring the remaining peroxide after incubation of PRDX2 and peroxide for 20min at RT. Specific activity is defined as the amount of hydroperoxide that 1ug of enzyme can reduce at 25C for 1 min. AA Sequence: MASGNARIGK PAPDFKATAV VDGAFKEVKL SDYKGKYVVL FFYPLDFTFV CPTEIIAFSN RAEDFRKLGC EVLGVSVDSQ FTHLAWINTP RKEGGLGPLN IPLLADVTRR LSEDYGVLKT DEGIAYRGLF IIDGKGVLRQ ITVNDLPVGR SVDEALRLVQ AFQYTDEHGE VCPAGWKPGS DTIKPNVDDS KEYFSKHN Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
