Plasminogen Activator Inhibitor Type 1, Human, stable mutant (PAI-1)

Produktübersicht

• Artikelname: Plasminogen Activator Inhibitor Type 1, Human, stable mutant (PAI-1)
• Artikelnummer: USB-P4256-29J
• Hersteller Artikelnummer: P4256-29J
• Alternativnummer: USB-P4256-29J-500
• Hersteller: US Biological
• Kategorie: Molekularbiologie

Produktbeschreibung

Description: Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angiogenesis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation (1). The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer (2,3,4). PAI-1 is activated by the glycoprotein vitronectin. Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration (5). This binding has proven to be an important inhibitor of the activated form of protein C (APC) (6). Epitope Location: N-Terminal Cysteine Solubility: >2mg/ml and <5mg/ml Form: Supplied as a liquid in 0.05M sodium phosphate, 0.1M sodium chloride, 1mM EDTA, 1mM DDT, pH 6.6 Purity: >98% pure by SDS PAGE 95 5% active by uPA titration Concentration: 2.9mg/ml Kinetic Data: Second order rate constants for inhibition of: uPA = 6.3 X 10e6 M -1s -1 tPA = 5.7 X 10e6 M -1s -1 Storage and Stability: May be stored at 4C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months

Produkteigenschaften

• Molekulargewicht: 43
• Reinheit: >98% pure by SDS PAGE 95 5% active by uPA titration
• Formulierung: Supplied as a liquid in 0.05M sodium phosphate, 0.1M sodium chloride, 1mM EDTA, 1mM DDT, pH 6.6