Plasminogen Activator Inhibitor Type 1, stable mutant, Human (PAI-1)

Produktübersicht

• Artikelname: Plasminogen Activator Inhibitor Type 1, stable mutant, Human (PAI-1)
• Artikelnummer: USB-P4256-29S
• Hersteller Artikelnummer: P4256-29S
• Alternativnummer: USB-P4256-29S-500
• Hersteller: US Biological
• Kategorie: Molekularbiologie

Produktbeschreibung

Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angiogenesis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation (1). The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer (2,3,4). PAI-1 is activated by the glycoprotein vitronectin. Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration (5). This binding has proven to be an important inhibitor of the activated form of protein C (APC) (6). Physical Appearance: Colorless frozen solution. Solubility: >2mg/ml and <5mg/ml Buffer Composition: 0.05M sodium phosphate, 0.1M sodium chloride, 1mM EDTA, pH 6.6. Purity: >99% pure by SDS PAGE 98% active by uPA titration. Absorbance (280nm): 3.3 E0.1% = 1.0 Concentration = 3.3mg/ml Active Concentration = 3.3mg/ml Kinetic Data: Second order rate constants for inhibition of: UPA = 5.1 X 106M -1s -1 tPA = 7.9 X 105M -1s -1 Storage and Stability: Store frozen at -70C - stable for 1 year

Produkteigenschaften

• Molekulargewicht: 43