Synthetic peptide from human Prion Protein, aa106-126. Sequence (linear): Lys-Thr-Asn-Met-Lys-His-Met-Ala-Gly-Ala-Ala-Ala-Ala-Gly-Ala-Val-Val-Gly-Gly-Leu-Gly Prions are large cell membrane-anchored glycoproteins that are normally localized to the presynaptic membrane of neurons in mammalian brain. Prions are likely to be involved in synaptic transmission. In prion diseases, such as Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler-Scheinker syndrome (GSS), Fatal Familial Insomnia (FFI), Alpers Syndrome, and Kuru, the normal cellular form of this protein (PrPc) is transformed into an altered, proteolysis-resistant form upon coming into contact with an infectious prion protein (PrPsc) from another host. This altered prion protein accumulates in cytoplasmic vesicles of diseased individuals, forming lesions, vacuoles, and amyloid deposits. This antiserum can routinely be used without further purification. Storage and Stability: Lyophilized powder may be stored at 4C for short-term only. Stable for 12 months at -20C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Reinheit:
95+% HPLC, Mass Spec
Formulierung:
Supplied as a white to off-white lyophilized powder.
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