| Semisynthetic antibiotic. Antibacerial (tuberculostatic). Inhibits RNA synthesis via RNA Polymerase binding. Specifically inhibits DNA-dependent RNA polymerase in bacteria by forming an inactive complex. Does not affect mammalian RNA polymerase. Synonyms: 3-[[(4-Methyl-1-piperazin-yl)imino]methyl]rifamycin, Abrifam, Ba 41166/E, Eremfat, Famcin, L 5103 Lepetit, NSC 113926, Refampicin, Rifa, Rifacap, Rifadin, Rifadine, Rifaldazine, Rifaldin, Rifampicin SV, Rifampin, Rifamycin AMP, Rifaprodin, Rifoldin, Rifoldine, Riforal, Rimactan, Rimactane, Rimapen, Sinerdol, Tubocin CAS No: 13292-46-1 Molecular Formula: C43H58N4O12 Molecular Weight: 822.94 Appearance: Orange to red/brown powder Purity: 96.5% Melting Point: >200C Identification: Conforms to IR, Spectrophotometric and Colorimetric analyses Solubility: Chloroform, DMSO, Alcohol: Insoluble, DMSO: 100mg/ml (121.51mM), Water: Insoluble pH: 4.5-6.5 Loss on Drying: 1% Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. |
