| The retinoid X receptor (RXR) is a pleiotropic nuclear receptor transcription factor that interacts with a variety of nuclear receptor dimeric partner. RXR binds cognate response elements as a homodimer in the presence of its ligand, 9-cis retinoic acid, or as a heterodimer with other members of the nuclear hormone receptor superfamily including retinoic acid receptors (RAR), thyroid hormone receptors (TR), vitamin D receptors and peroxisome proliferators-activated receptors (PPAR). The RXR family includes three difference isoforms, RXR alpha, beta, gamma. Human RXR alpha gene is localized on 9q34.9 and encodes two major isoforms (RXRa1, RXRa2). The DNA binding domain of RXR (111-228aa) was overexpressed in E.coli. Molecular Weight: 13.6kD (119 amino acids) Sequence: MLGLNGVLKV/ PAHPSGNMAS/ FTKHICAICG/ DRSSGKHYGV/ YSCEGCKGFF/ KRTVRKDLTY/ TCRDNKDCLI/ DKRQRNRCQY/ CRYQKCLAMG/ MKREAVQEER/ QRGKDRNENE/ VESTSSANE Storage and Stability: May be stored at 4C for short-term only. For long-term storage, store at -20C. Aliquots are stable for at least 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
