SAPK2, p38 MAPK Inhibitor (SB 202190) (Stress-activated Protein Kinase 2), CAS [[152121-30-7]]

Produktübersicht

• Artikelname: SAPK2, p38 MAPK Inhibitor (SB 202190) (Stress-activated Protein Kinase 2), CAS [[152121-30-7]]
• Artikelnummer: USB-S0096-25
• Hersteller Artikelnummer: S0096-25
• Alternativnummer: USB-S0096-25-1
• Hersteller: US Biological
• Kategorie: Molekularbiologie

Produktbeschreibung

SB 202190 is a cell permeable pyridinyl imidazole, which acts as a strong inhibitor of SAPK2a/p38 and SAPK2b/p38beta MAP kinases (IC50=280nM and 350nM, respectively). SB 202190 has no effect on the activity of the Erk or SAPK/JNK MAP kinases and is reported to block LPS induced TNF-a and IL-1beta production in mice. The compound is a slightly better inhibitor than the related compound SB 203580. Solubility: Soluble in DMSO (50mg/ml). Applications: Specific inhibitor of p38/SAPK2a MAPK and P38b/SAPK2a MAPK activity. Other applications not tested. Protein Kinase Inhibition Assay: When pre-incubated for five minutes with 0.2ug of SAPK2a/p38 MAPK or SAPK2b/p38beta MAPK, 1-10uM of SB 202190 will inhibit the activity of these kinases 80-95%. The final concentration of SB 202190 needed may depend on the amount of enzyme used. Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months after receipt at -20C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Note: Protect from light.

Produkteigenschaften

• Molekulargewicht: 331.3
• NCBI: 002751
• UniProt: Q15759
• Reinheit: 98% (HPLC)
• Formulierung: Supplied as a pale yellow solid.
• CAS Nummer: [152121-30-7]