SH2D1A, Recombinant, Human (SH2 Domain-containing Protein 1A, Duncan Disease SH2-protein, Signaling Lymphocytic Activation Molecule-associated Protein, SLAM-associated Protein T-cell Signal Transduction Molecule SAP, DSHP, SAP)
Artikelnummer:
USB-S1013-31E4
Hersteller Artikelnummer:
S1013-31E4
Alternativnummer:
USB-S1013-31E4-100
Hersteller:
US Biological
Kategorie:
Molekularbiologie
SH2D1A is an inhibitor of the signaling lymphocyte activation molecule (SLAM) self-association. This protein is expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Defects in SH2D1A are a cause of X-linked lymphoproliferative disease (XLPD) also known as Duncan disease. XLPD is characterized by a rare congenital immunodeficiency following Epstein-Barr virus (EBV) infection. Source: Recombinant corresponding to aa1-128 of human SH2D1A protein, fused to His-tag at N-terminus, expressed in E. coli. Accession: NP_002342. Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MDAVAVYHGK ISRETGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYHGY IYTYRVSQTE TGSWSAETAP GVHKRYFRKI KNLISAFQKP DQGIVIPLQY PVEKKSSARS TQGTTGIRED PDVCLKAP Molecular Weight: 16.3kD (148aa) confirmed by MALDI-TOF Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
