| A short chain fatty acid shown to be an inhibitor of histone deacetylase (HDAC). Induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and inteferes with signal transduction processes, including the release of Ca2+ from intracellular stores. Downregulates the activity of serine/threonine protease kinase casein kinase II in HT29 cells. Sodium Butyrate: CAS Number: 156-54-7 Molecular Formula: C4H7NaO2 Molecular Weight: 110.09 Applications: For use as a histone deacetylase inhibitor. Recommended Dilutions: 1, 5, 20 and 100mM showed >70% inhibition of HDAC activity in HeLa nuclear extract using H5109-62: Histone Deacetylase (HDAC), BioAssay(TM) Fluorometric Detection Kit. Optimal dilutions to be determined by the researcher. Storage and Stability: Store at 4C. Stable for 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. |
