Staurosporine is an alkaloid isolated from the culture broth of Streptomyces staurospores and is a super-potent, cell permeable PKC inhibitor (IC50=0.7), at higher concentrations Staurosporine inhibits other protein kinases: CDK2/cyclin A (IC50=7uM) and CDK4/cyclin D (IC50=3-10uM). At a concentration of 50-100nM it is a functional neurotrophins agonist promoting neurite outgrowth in neuroblastoma, pheochromocytoma and brain primary neuronal cultures. Staurosporine inhibits a variety of kinases including PKA, PKG, MLCK, CaMK, tyrosine kinases, and phosphorylase kinase. This compound displays selectivity toward the PKC isoforms, inhibiting PKCalpha, PKCbeta, PKCgamma, PKCdelta, and PKCepsilon, but not PKCxi, and induces PKC translocation. Staurosporine also inhibits topoisomerase II directly by interaction with the ATP binding site, augments PMA-induced ornithine decarboxylase, and activates a bcl-2-regulated apoptosis pathway. Source: Streptomyces staurosporeus Synonyms: Antibiotic AM2282, Antibiotic 230, CCRIS 3272 CAS No: 62996-74-1 Molecular Formula: C28H26N4O3 Molecular Weight: 466.53 Appearance: Supplied as a liquid in DMSO. Purity (HPLC): 98% Storage and Stability: Stable in solution for one week at 4C. Three months at -20C. Protect from light.
Molekulargewicht:
466.53
Reinheit:
98% (HPLC)
Formulierung:
Supplied as a liquid in DMSO.
CAS Nummer:
[62996-74-1]
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