Sunitinib (as the malate salt) is the active ingredient in the drug sold under the trade name Sutent. This drug is a small molecule receptor tyrosine kinase inhibitor that has been approved in at least one country for the treatment of patients having gastrointestinal stromal tumors or renal cell carcinomas. Synonyms: N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, SU-11248, Sutent, PHA-290940AD, PNU-290940AD CAS No: 557795-19-4 Molecular Formula: C22H27FN4O2 Molecular Weight: 398.47 Appearance: Yellow powder Purity: 99% (HPLC, TLC) Solubility: Soluble in DMSO at 40mg/ml, soluble in ethanol at 1.4mg/ml with warming, very poorly soluble in water, maximum solubility in plain water is estimated to be about 10-20uM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Elemental Analysis Calculated: %C: 66.31 %H: 6.83 %F: 4.77 %N: 14.06 Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with DMSO or EtOH. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molekulargewicht:
398.47
CAS Nummer:
[557795-19-4]
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
