Synuclein, alpha, Recombinant, Human (Alpha-synuclein, SNCA, MGC110988, Non-A beta Component of AD Amyloid, Non-A4 Component of Amyloid Precursor, NACP, PARK1, PARK4, PD1)

Produktübersicht

• Artikelname: Synuclein, alpha, Recombinant, Human (Alpha-synuclein, SNCA, MGC110988, Non-A beta Component of AD Amyloid, Non-A4 Component of Amyloid Precursor, NACP, PARK1, PARK4, PD1)
• Artikelnummer: USB-S9500-01P
• Hersteller Artikelnummer: S9500-01P
• Alternativnummer: USB-S9500-01P-100
• Hersteller: US Biological
• Kategorie: Molekularbiologie

Produktbeschreibung

Alpha-Synuclein (aa1-140), an acidic neuronal protein of 140 aa, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. Alpha- synuclein has been suggested to be implicated in the pathogenesis of Parkinsons disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Moreover, recent studies have shown that Alpha-synuclein has chaperone activity and that this activity is lost upon removing its C-terminal acidic tail (amino acids 96-140). Sequences of Amino Acids: MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA Molecular Weight: ~14.4kD Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 14.4
• NCBI: 000336
• Reinheit: ~95% (SDS-PAGE)
• Formulierung: Supplied as a lyophilized powder from 20mM Tris-HCl buffer, pH 7.5, 100mM sodium chloride, 1mM magnesium chloride. Reconstitute in sterile dH2O at a concentration of < 1mg/ml.