Alpha synuclein (aa1-140), an acidic neuronal protein of 140 aa, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. Alpha synuclein has been suggested to be implicated in the pathogenesis of Parkinsons disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Moreover, recent studies have shown that alpha synuclein has chaperone activity and that this activity is lost upon removing its C-terminal acidic tail (aa96-140). Recombinant protein corresponding to aa1-140 from human NACP, expressed in E. coli. Amino Acid Sequence: MDVFMKGLSK/ AKEGVVAAAE/ KTKQGVAEAA/ GKTKEGVLYV/ GSKTKEGVVH/ GVATVAEKTK/ EQVTNVGGAV/ VTGVTAVAQK/ TVEGAGSIAA/ ATGFVKKDQL/ GKNEEGAPQE/ GILEDMPVDP/ DNEAYEMPSE/ EGYQDYEPEA Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molekulargewicht:
14.4
Reinheit:
95% by SDS PAGE. Endotoxin: 1EU/ug (LAL).
Formulierung:
Supplied as a liquid in 20mM Tris-HCl, pH 7.5, 0.1M sodium chloride, 1mM magnesium chloride
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