TL1A (TNFSF15, Tumor Necrosis Factor Ligand Superfamily Member 15), Rabbit
Artikelnummer:
USB-T8038-05
Hersteller Artikelnummer:
T8038-05
Alternativnummer:
USB-T8038-05-100
Hersteller:
US Biological
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
WB
Immunogen:
Peptide corresponding to 14aa, aa60-110, near the N-terminus of human TL1A.
Members in the TNF and its receptor superfamilies regulate immune responses and induce apoptosis. DR3 (also termed Wsl-1, Apo-3, TRAMP, and LARD) (1-5) is preferentially expressed by T lymphocytes and upregulated during T cell activation. The ligand for DR3 was recently identified and designated TL1A (6). TL1A also binds decoy receptor DcR3/TR6 (7,8), which is expressed in several lung and colon carcinomas and in some normal tissues. TL1A induces apoptosis and NF-kB activation in DR3 expressing cells, which is antagonized by DcR3. TL1A is upregulated by proinflammatory cytokines TNF and IL-1. TL1A is a longer variant of TL1 (also called VEGI). Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
