Synthetic peptide corresponding to 14aa near the middle of human TLR10. Epitope: aa600-650. Species Sequence Homology: bovine
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. TLR10 is highly homologous to TLRs 1 and 6 and is most highly expressed in lymphoid tissues. Most recently genetic variation in TLR10 has been associated with contributing to asthma risk. It should be noted that TLR10 exists in mice only as a pseudogene. Applications: Suitable for use in Western Blot, ELISA and Immunofluorescence. Other applications not tested. Recommended Dilutions: Western Blot: 0.5-1ug/ml, a band corresponding to TLR10 is observed at ~75kD Immunofluorescence: 2ug/ml Optimal dilution determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
