Synthetic peptide corresponding to C-NKTLEKMEKHRK, from human TFAP2C, at C-terminal. Species sequence homology: Bovine, canine, mouse, porcine and rat.
Transcription factor gene AP2-C (AP-2 gamma) belongs to a family of four closely related genes. The AP-2 transcription factor has been shown to play an important role in the development of tissues of ectodermal origin and has also been implicated in mammary oncogenesis. A physical and functional association between AP-2gamma transcription factor and the Wwox protein has been demonstrated. results suggest that Wwox tumor suppressor protein inhibits AP-2gamma oncogenic activity by sequestering it in the cytoplasm. P-2 gamma had been implicated in multiple functions during proliferation and differentiation based on its expression pattern in trophoblast, neural crest, and ectoderm cells in murine embryos. AP-2 gamma seems to be required in early embryonic development because it regulates the genetic programs controlling proliferation and differentiation of extraembryonic trophectodermal cells. Applications: Suitable for use in Peptide ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: Peptide ELISA: 1:128,000 Immunohistochemistry (Paraffin): 2-3ug/ml with steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
