TGFBR1 (TGF-beta Receptor Type I, TGFR-1, Transforming Growth Factor-beta Receptor Type I, TGF-beta Type I Receptor, TbetaR-I, TGF-beta Type I Receptor, Serine/Threonine-protein Kinase Receptor R4, SKR4, Activin Receptor-like Kina

Produktübersicht

• Artikelname: TGFBR1 (TGF-beta Receptor Type I, TGFR-1, Transforming Growth Factor-beta Receptor Type I, TGF-beta Type I Receptor, TbetaR-I, TGF-beta Type I Receptor, Serine/Threonine-protein Kinase Receptor R4, SKR4, Activin Receptor-like Kina
• Artikelnummer: USB-T8250-31D
• Hersteller Artikelnummer: T8250-31D
• Alternativnummer: USB-T8250-31D-50
• Hersteller: US Biological
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: IHC
• Immunogen: Synthetic peptide corresponding to aa158-179 of human TGFBR1.

Produktbeschreibung

Transforming growth factor beta (TGFB) inhibits cell proliferation and stimulates cell differentiation. This is achieved through a receptor complex of types I and II TGFB receptors. The type II receptor is a transmembrane serine/threonine kinase which is able to bind TGFB and transactivate the type I receptor. TGFB receptors are found in all myometrial tissues and, in the kidney, they are found exclusively in renal tubular cells. In normal gastric mucosa, type I and II receptors are demonstrated in fundic glands, but not on surface mucous cells and in normal small bowel and colon, TGFB receptors are expressed in the epithelial cells of the upper crypts. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 15ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Produkteigenschaften

• Reinheit: Purified by immunoaffinity chromatography.
• Formulierung: Supplied as a liquid in 10mM PBS, 1% BSA, pH 7.4, 0.09% sodium azide.