TRIB1, CT (Tribbles Homolog 1, TRB-1, SKIP1, G-protein-coupled Receptor-induced Protein 2, GIG-2, TRIB1, C8FW, GIG2), Rabbit
Artikelnummer:
USB-T8335-40B
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| Artikelname: | TRIB1, CT (Tribbles Homolog 1, TRB-1, SKIP1, G-protein-coupled Receptor-induced Protein 2, GIG-2, TRIB1, C8FW, GIG2), Rabbit |
| Artikelnummer: | USB-T8335-40B |
| Hersteller Artikelnummer: | T8335-40B |
| Alternativnummer: | USB-T8335-40B-200 |
| Hersteller: | US Biological |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | ELISA, WB |
| Immunogen: | Synthetic peptide selected from the C-terminal region of human TRIB1 (KLH). |
| TRIB1 antibody, also called gprotein coupled receptor induced, skip1, gig2, c8fwATP, functions in binding protein binding, protein kinase inhibitor activity, and protein serine/threonine kinase activities Overexpression of TRIB1 in HeLa cells repressed the basal activity of the IL8 promoter by inhibiting AP1 activity. Overexpression of TRIB1 inhibited oncogenic Ras -driven AP1 activation and MEKK1-mediated AP1 activation. ERK activation was enhanced by TRIB1. Coimmunoprecipitation and yeast 2-hybrid assays showed that MEK1 interacted with both TRIB1 and TRIB3, and MKK4 interacted specifically with TRIB1. Cotransfection of MKK4 enhanced the level of TRIB1, indicating that the TRIB-MAPKK interaction stabilized TRIB1. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-1:500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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