| Trinactin is a member of the macrotetrolide complex produced by a range of Streptomyces sp. Early literature reported that trinactin is a monovalent cation ionophore with high selectivity for ammonium and potassium. Trinactin inhibited T-cell proliferation induced by IL-2 and cytokine production at nonomolar levels for IL-2, IL-4, IL-5 and interferon-gamma. Trinactin has not previously been available for intensive investigation. Synonyms: (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-5,14,23-Triethyl-2,11,20,29,32-pentamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone, [1R-(1R*,2R*,5R*,7R*,10S*,11S*,14S*,16S*,19R*,20R*,23R*,25R*,28S*,29S*,32S*,34S*)]-5,14,23-Triethyl-2,11,20,29,32-pentamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone, Trinactin, 5,14,23-Tridemethyl-5,14,23-triethyl-nonactin, 5,14,23-Triethyl-2,11,20,29,32-pentamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone CAS No: 7561-71-9 Molecular Formula: C43H70O12 Purity (HPLC): 95% Solubility: Ethanol, methanol, DMF or DMSO. Limited water solubility. Storage and Stability: Store at 4C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. |
