Troponin I, Cardiac, aa23-29 (cTnI, CMH7, Familial Hypertrophic Cardiomyopathy 7, TNNC1, Troponin I Type 3 Cardiac, TNNI3) (PE), IgG2a, Clone: [1.BB.143], Mouse, Monoclonal

Produktübersicht

• Artikelname: Troponin I, Cardiac, aa23-29 (cTnI, CMH7, Familial Hypertrophic Cardiomyopathy 7, TNNC1, Troponin I Type 3 Cardiac, TNNI3) (PE), IgG2a, Clone: [1.BB.143], Mouse, Monoclonal
• Artikelnummer: USB-T8665-18B-PE
• Hersteller Artikelnummer: T8665-18B-PE
• Alternativnummer: USB-T8665-18B-PE-100
• Hersteller: US Biological
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: FLISA, WB
• Immunogen: Native troponin complex. Epitope: aa 23- 29.

Produktbeschreibung

Troponin, working in conjunction with tropomyosin, functions as a molecular switch, regulating muscle contraction in response to changes in the intracellular Ca2+ concentration. Troponin consists of three subunits, the Ca2+-binding subunit troponin C (TnC), the tropomyosin-binding subunit troponin T (TnT), and the inhibitory subunit troponin I (TnI). Troponin I binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place, because of which myosin cannot bind to actin in relaxed muscle. When Calcium binds to the Troponin C it causes certain confomational changes which leads to dislocation of troponin I. The letter ''I is given due to its inhibitory character. The tissue specific subtypes are: Slow-twitch skeletal muscle isoform troponin I, TNNI1 (1q31.3, 191042) Fast-twitch skeletal muscle isoform troponin I, TNNI2 (11p15.5, 191043) Cardiac troponin I, TNNI3 (19q13.4, 191044) Applications: Suitable for use in FLISA, Western Blot and Immunoaffinity Purification. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Hybridoma: SP2/0 myeloma cells with spleen cells from Balb/c mice. Storage and Stability: Store product at 4C in the dark. DO NOT FREEZE! Stable at 4C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [1.BB.143]
• Isotyp: IgG2a
• Reinheit: Purified by Protein A affinity chromatography.
• Formulierung: Supplied as a liquid in PBS, pH 7.2. No preservative added. No stabilizing proteins added. Labeled with R-Phycoerythrin (PE).