Tryptophan Hydroxylase, Tyrosine Hydroxylase & Phenylalanine Hydroxylase (TH, TYH, TRH, TYH, PAH, PH8, Tyrosine 3 Hydroxylase, Tyrosine 3 Monooxygenase), IgG1, Clone: [2Q122 PH8], Mouse, Monoclonal
Artikelnummer:
USB-T9014-70
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| Artikelname: | Tryptophan Hydroxylase, Tyrosine Hydroxylase & Phenylalanine Hydroxylase (TH, TYH, TRH, TYH, PAH, PH8, Tyrosine 3 Hydroxylase, Tyrosine 3 Monooxygenase), IgG1, Clone: [2Q122 PH8], Mouse, Monoclonal |
| Artikelnummer: | USB-T9014-70 |
| Hersteller Artikelnummer: | T9014-70 |
| Alternativnummer: | USB-T9014-70-500 |
| Hersteller: | US Biological |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | IHC, IP, WB |
| Immunogen: | Human phenylalanine hydroxylase sequence between aa139-155 (NM_004179.1). |
| Tyrosine hydroxylase (TYH) is the enzyme which converts tyrosine to dihydroxyphenylalanine (L-dopa), a precursor of the catecholamine neurotransmitters dopamine, noradrenaline and adrenaline. Tryptophan hydroxylase (TRH) is the enzyme that converts 5-hydroxytryptophan to serotonin. In fresh tissue, the antibody binds to TYH and TRH. So it is a marker for TYH-containing catecholaminergic neurons and serotonergic neurons. Tryptophan hydroxylase (TRH) can be used as a marker for serotonin as it converts 5-hydroxytryptophan to serotonin. Serotonin is rapidly metabolized and is unable to be detected by anti-serotonin antibodies in post mortem tissue. In human tissue that has been formalin-fixed, due to a change in the antigenic determinant of tyrosine hydroxylase (TYH), the antibody binds only tryptophan hydroxylase (TRH). Used to specifically identify serotonergic neurons in fixed human tissue. Phenylalanine hydroxylase (PAH) can also be detected in hepatic tissue sections. Applications: Suitable for use in Immunohistochemistry, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilutions: Immunohistochemistry: 1:2000-1:10,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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