UBE1C, CT (Ubiquitin-activating Enzyme E1C, NEDD8-activating Enzyme E1 Catalytic Subunit, Ubiquitin-like Modifier-activating Enzyme 3, Ubiquitin-activating Enzyme 3, NEDD8-activating Enzyme E1C, UBA3), Rabbit
Artikelnummer:
USB-U0882-10B
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| Artikelname: | UBE1C, CT (Ubiquitin-activating Enzyme E1C, NEDD8-activating Enzyme E1 Catalytic Subunit, Ubiquitin-like Modifier-activating Enzyme 3, Ubiquitin-activating Enzyme 3, NEDD8-activating Enzyme E1C, UBA3), Rabbit |
| Artikelnummer: | USB-U0882-10B |
| Hersteller Artikelnummer: | U0882-10B |
| Alternativnummer: | USB-U0882-10B-200 |
| Hersteller: | US Biological |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | ELISA, IHC, WB |
| Immunogen: | Synthetic peptide selected from the C-terminal region of human UBE1C (KLH). |
| The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Immunohistochemistry: 1:50-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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