Recombinant protein corresponding to human VEGF121. Cellular Localization: Cytoplasmic, cell surface and extracellular matrix.
VEGF (Vascular Endothelial Growth Factor) is a homodimeric, disulfide-linked glycoprotein involved in angiogenesis which promotes tumor progression and metastasis. It exhibits potent mitogenic and permeablility inducing properties specific for the vascular endothelium. Multiple isoforms of VEGF containing 206-, 189-, 165-, and 121-amino acid residues have been described which arise from alternative splicing of a single gene. The smaller two isoforms, VEGF165 and VEGF121, are secreted proteins and act as diffusible agents, whereas the larger two remain cell-associated. VEGF/VPF plays an important role in angiogenesis, which promotes tumor progression and metastasis. Applications: Suitable for use in Neutralization of the bioactivity of human VEGF. Other applications have not been tested. Recommended Dilution: Neutralization: Azide removal is required prior to use. Optimal dilutions to be determined by the researcher. Positive Control: Angiosarcoma Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Klonalität:
Monoclonal
Klon-Bezeichnung:
[0.N.600 JH121]
Reinheit:
Purified by Protein G affinity chromatography from ascites.
Formulierung:
Supplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide.
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
