WWOX, aa1-234, Recombinant, Human, His-Tag (WWOX, WW domain containing oxidoreductase, FOR, FRA16D, HHCMA56, PRO0128, WWOX v8, FOR II protein, WW domain-containing oxidoreductase, WW domain-containing protein WWOX, fragile 16D oxi
Artikelnummer:
USB-W9100-12
Hersteller Artikelnummer:
W9100-12
Alternativnummer:
USB-W9100-12-50
Hersteller:
US Biological
Kategorie:
Molekularbiologie
WWOX, also known as WW domain containing oxidoreductase, is a proapoptotic protein and a tumor suppressor protein. WWOX is found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This protein may function synergistically with TP53/p53 to control genotoxic stress-induced cell death. It also plays a role in tumor necrosis factor (TNF)-mediated cell death. Source: Recombinant human WWOX protein, fused to His-tag at N-terminus, was expressed in E.coli. Molecular Weight: 28.3kD (254aa) AA Sequence: MGSSHHHHHH SSGLVPRGSH MSDIEEVVEE YEEEEQEEAA VEEQEEAAEE DAEAEAETEE TRAEEDEEEE EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI HRKRMEKDLN ELQALIEAHF ENRKKEEEEL VSLKDRIERR RAERAEQQRI RNEREKERQN RLAEERARRE EEENRRKAED EARKKKALSN MMHFGGYIQK TERKSGKRQT EREKKKKILA ERRKVLAIDH LNEDQLREKA KELWQSIYNL EAEKFDLQEK FKQQKYEINV LRNRINDNQK VSKTRGKAKV TGRWK Enzyme Activity: Not determined. This product is recommended for use in applications that do not require a catalytically active form of the protein. Storage and Stability: May be stored at 4C for short-term only. For long-term storage, aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
