| The breast cancer susceptibility gene, BRCA1, which maps to chromosome 17q is expressed in numerous tissues, including breast and ovary. A second breast cancer susceptibility gene, BRCA2, located on chromosome 13q12-13, also confers a high incidence of breast and ovarian cancer. Mutations within the BRCA1 gene may account for at least 80% of families with increased incidence of both early-onset breast cancer and ovarian cancer.This adenovirus expresses the human BRCA1 transcript variant 5 (NM_007299). This variant differs in the 5 UTR, uses two alternate in-frame splice sites in the central coding region, and lacks an alternate exon in the 3 coding region that results in a frameshift, compared to variant 1. So this variant is shorter and has a distinct C-terminus, compared to BRCA1 isoform 1.Please contact us if you need adenoviruses expressing other isoforms of human BRCA1. |
