| The superoxide-generating NADPH oxidase is present in phagocytes, neuroepithelial bodies, vascular smooth muscle cells and endothelial cells. It includes a membrane-bound flavocytochrome containing gp91-phox, Nox4 and p22-phox, and the cytosolic proteins, p40-phox, p47-phox and p67-phox. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with the flavocytochrome cytochrome b558 to form the active enzyme complex. Mox1 is largely similar to gp91 and is involved in regulating NADPH oxidase activity in non-phagocytic cells. |
