2019-nCoV Spike protein RBD, HIS Tag

Product Overview

• Article Name: 2019-nCoV Spike protein RBD, HIS Tag
• Biozol Catalog Number: SCM-C19SD-G241H
• Supplier Catalog Number: C19SD-G241H
• Alternative Catalog Number: SCM-C19SD-G241H-10,SCM-C19SD-G241H-100,SCM-C19SD-G241H-20,SCM-C19SD-G241H-50
• Manufacturer: SignalChem
• Host: SARS-CoV-2
• Category: Proteine/Peptide
• Species Reactivity: Virus
• Alternative Names: 2019-nCoV RBD, SARS-CoV-2 spike RBD, novel coronavirus spike RBD, nCov spike RBD

Product Description

2019-nCoV Spike protein RBD, HIS Tag

Additional Information

2019-nCoV Spike protein RBD

Recombinant 2019-nCoV Spike protein S1 subunit, receptor-binding domain (RBD) (319-541) was expressed in CHO cells using a C-terminal his tag.
Catalog No. C19SD-G241H

Overview:

The severe acute respiratory syndrome related novel coronavirus SARS-CoV-2 has caused the pandemic of the respiratory diseases (COVID-19) around the world in 2020 (1). The spike glycoprotein (S) of coronavirus belongs to the type I transmembrane protein, which contains two subunits, S1 and S2 (2), which is also known to be the key component to bind with host cells through the interaction with angiotensin-converting enzyme 2 (ACE2) (3). A receptor binding domain (RBD) of S1 can recognize the cell surface receptor and the mutation of RBD could cause higher motility rate (3).

 

Gene Aliases:

2019-nCoV RBD, SARS-CoV-2 spike RBD, novel coronavirus spike RBD, nCov spike RBD

 

Genbank Number:

MN908947

 

References:

1. Zhou P, et al: A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020, 579:270-89.

2. Xiao X, et al: The SARS-CoV S glycoprotein. Cell Mol Life Sci. 2004, 61 (19-20): 2428-30.

3. Lan J, et al: Crystal structure of the 2019-nCov spike receptor-binding domain bound with the ACE2 receptor. bioRxiv. doi: https://doi.org/10.1101/2020.02.19.956235.

 

Activity:

For specific information on a given lot, see related technical data sheet.

 

Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.

 

Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

 

Molecular Weight:

39 kDa

Product Properties

• Molecular Weight: 39 kDa
• Tag: HIS
• UniProt: MN908947
• Buffer: 50mM sodium phosphate, pH 7.5, 300mM NaCl, 150mM imidazole
• Source: Recombinant 2019-nCoV Spike protein S1 subunit, receptor-binding domain (RBD) (319-541) was expressed in CHO cells using a C-terminal his tag.
• Expression System: CHO Cells

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