Nilotinib, Free Base (AMN107), CAS [[641571-10-0]]

Produktübersicht

• Artikelname: Nilotinib, Free Base (AMN107), CAS [[641571-10-0]]
• Artikelnummer: USB-N2567-18
• Hersteller Artikelnummer: N2567-18
• Alternativnummer: USB-N2567-18-25
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

Nilotinib, a novel, selective BCR-ABL inhibitor, fits into the ATP-binding site of the BCR-ABL protein with higher affinity than imatinib. Nilotinib is not only more potent than imatinib against wild-type BCR-ABL (IC50 < 30nM), but also significantly active against 32/33 imatinib-resistant BCR-ABL mutants. Melting Point: 242.5-245C Solubility: Soluble in DMSO at 50mg/ml, very poorly soluble in ethanol, very poorly soluble in water, maximum solubility in plain water is estimated to be about 10-20uM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Elemental Analysis: Calculated C - 63.51% H - 4.19% F - 10.76% N - 18.52% Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Produkteigenschaften

• Molekulargewicht: 529.52
• Reinheit: ~99% (by HPLC and TLC)
• Formulierung: Supplied as an off-white powder
• CAS Nummer: [641571-10-0]