Nilotinib, Free Base (AMN107), CAS [[641571-10-0]]
Biozol Catalog Number:
USB-N2567-18
Supplier Catalog Number:
N2567-18
Alternative Catalog Number:
USB-N2567-18-25
Manufacturer:
US Biological
Category:
Biochemikalien
Nilotinib, a novel, selective BCR-ABL inhibitor, fits into the ATP-binding site of the BCR-ABL protein with higher affinity than imatinib. Nilotinib is not only more potent than imatinib against wild-type BCR-ABL (IC50 < 30nM), but also significantly active against 32/33 imatinib-resistant BCR-ABL mutants. Melting Point: 242.5-245C Solubility: Soluble in DMSO at 50mg/ml, very poorly soluble in ethanol, very poorly soluble in water, maximum solubility in plain water is estimated to be about 10-20uM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Elemental Analysis: Calculated C - 63.51% H - 4.19% F - 10.76% N - 18.52% Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
529.52
Purity:
~99% (by HPLC and TLC)
Form:
Supplied as an off-white powder
CAS Number:
[641571-10-0]
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