Predicted to enable signaling receptor binding activity. Involved in several processes, including CD40 signaling pathway, activation of phospholipase C activity, and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including cellular response to lipopolysaccharide, defense response to virus, and positive regulation of T cell proliferation. Located in external side of plasma membrane and intracellular membrane-bounded organelle. Is expressed in central nervous system and retina. Used to study Guillain-Barre syndrome. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura, autoimmune disease (multiple), chronic lymphocytic leukemia, chronic obstructive pulmonary disease, and systemic scleroderma. Orthologous to human CD86 (CD86 molecule).
Cross-Reactivity: Mouse. ResearchArea: Immunology Adaptive Immunity T Cells CDImmunology Cell Type Markers CD Non-lineageMicrobiology Interspecies Interaction Host Virus InteractionStem Cells Hematopoietic Progenitors Lymphoid B Lymphocytic LineageStem Cells Hematopoietic Progenitors Myeloid Dendritic Cell LineageStem Cells Hematopoietic Progenitors Myeloid Monocytic LineageImmunology Adaptive Immunity Regulatory T Cells. Shipping: Ice Bag
Flow cytometry:1X10 6 C57BL/6 Mouse Bone Marrow cells (negative control,left) and C57BL/6 Mouse Bone Marrow-Derived M0 Macrophages (right) were surface-stained with ABflo 450 Rabbit anti-Mouse CD11b mAb (A26229,5 µl/Test) and APC Rabbit anti-Mouse CD86 mAb (A25824,5 µl/Test).
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