KDM4B/JMJD2B Rabbit pAb, Unconjugated, Polyclonal

Produktübersicht

• Artikelname: KDM4B/JMJD2B Rabbit pAb, Unconjugated, Polyclonal
• Artikelnummer: ABB-A5824
• Hersteller Artikelnummer: A5824
• Alternativnummer: ABB-A5824-100UL,ABB-A5824-20UL,ABB-A5824-1000UL,ABB-A5824-500UL
• Hersteller: ABclonal
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ELISA, WB
• Spezies Reaktivität: Human
• Immunogen: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
• Konjugation: Unconjugated
• Alternative Synonym: MRD65, JMJD2B, TDRD14B, KDM4B/JMJD2B

Produktbeschreibung

Enables histone H3-methyl-lysine-36 demethylase activity and histone H3-methyl-lysine-9 demethylase activity. Involved in histone H3-K36 demethylation and histone H3-K9 demethylation. Located in cytosol and nucleoplasm. Implicated in autosomal dominant non-syndromic intellectual disability, breast cancer, colorectal cancer, malignant peripheral nerve sheath tumor, and stomach cancer. Biomarker of several diseases, including alopecia areata, lung cancer, medulloblastoma, prostate cancer, and stomach cancer.

Produkteigenschaften

• Klonalität: Polyclonal
• Molekulargewicht: 122kDa
• NCBI: 23030
• UniProt: O94953
• Reinheit: Affinity purification
• Sequenz: MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYG
• Target-Kategorie: KDM4B
• Antibody Type: Primary Antibody

Anwendungsbeschreibung

• Application Verdünnung: WB,1:500 - 1:1000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Anwendungsbeschreibung: Cross-Reactivity: Human,Mouse. ResearchArea: Epigenetics Nuclear Signaling,Epigenetic writers and erasers of core Histones,DNA Damage Repair,Nuclear Receptor Signaling,Signal Transduction,Kinase,Serine threonine kinases,Cell Biology Developmental Biology,Cell Cycle,Immunology Inflammation. Shipping: Ice Bag

Bilder

Western blot analysis of lysates from Mouse brain, using (A5824) at 1:1000 dilution.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 30s.