KDM4B/JMJD2B Rabbit pAb, Unconjugated, Polyclonal

Product Overview

• Article Name: KDM4B/JMJD2B Rabbit pAb, Unconjugated, Polyclonal
• Biozol Catalog Number: ABB-A5824
• Supplier Catalog Number: A5824
• Alternative Catalog Number: ABB-A5824-100UL,ABB-A5824-20UL,ABB-A5824-1000UL,ABB-A5824-500UL
• Manufacturer: ABclonal
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, WB
• Species Reactivity: Human
• Immunogen: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
• Conjugation: Unconjugated
• Alternative Names: MRD65, JMJD2B, TDRD14B, KDM4B/JMJD2B

Product Description

Enables histone H3-methyl-lysine-36 demethylase activity and histone H3-methyl-lysine-9 demethylase activity. Involved in histone H3-K36 demethylation and histone H3-K9 demethylation. Located in cytosol and nucleoplasm. Implicated in autosomal dominant non-syndromic intellectual disability, breast cancer, colorectal cancer, malignant peripheral nerve sheath tumor, and stomach cancer. Biomarker of several diseases, including alopecia areata, lung cancer, medulloblastoma, prostate cancer, and stomach cancer.

Product Properties

• Clonality: Polyclonal
• Molecular Weight: 122kDa
• NCBI: 23030
• UniProt: O94953
• Purity: Affinity purification
• Sequence: MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYG
• Target: KDM4B
• Antibody Type: Primary Antibody

Application Notes

• Application Dilute: WB,1:500 - 1:1000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Application Notes: Cross-Reactivity: Human,Mouse. ResearchArea: Epigenetics Nuclear Signaling,Epigenetic writers and erasers of core Histones,DNA Damage Repair,Nuclear Receptor Signaling,Signal Transduction,Kinase,Serine threonine kinases,Cell Biology Developmental Biology,Cell Cycle,Immunology Inflammation. Shipping: Ice Bag

Images

Western blot analysis of lysates from Mouse brain, using (A5824) at 1:1000 dilution.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 30s.