TFPI Rabbit mAb, Unconjugated

Produktübersicht

• Artikelname: TFPI Rabbit mAb, Unconjugated
• Artikelnummer: ABB-A8704
• Hersteller Artikelnummer: A8704
• Alternativnummer: ABB-A8704-20UL, ABB-A8704-100UL
• Hersteller: ABclonal
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ELISA, WB
• Spezies Reaktivität: Human
• Immunogen: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
• Konjugation: Unconjugated
• Alternative Synonym: EPI, TFI, LACI, TFPI1, TFPI

Produktbeschreibung

This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization.

Produkteigenschaften

• Molekulargewicht: 35kDa
• NCBI: 7035
• UniProt: P10646
• Reinheit: Affinity purification
• Target-Kategorie: TFPI

Anwendungsbeschreibung

• Application Verdünnung: WB,1:500 - 1:1000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Anwendungsbeschreibung: Cross-Reactivity: Human, ResearchArea: Cardiovascular,Blood.

Bilder

Western blot analysis of lysates from BxPC-3 cells, using TFPI Rabbit mAb (A8704) at 1:1000 dilution.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 10s.