TFPI Rabbit mAb, Unconjugated

Product Overview

• Article Name: TFPI Rabbit mAb, Unconjugated
• Biozol Catalog Number: ABB-A8704
• Supplier Catalog Number: A8704
• Alternative Catalog Number: ABB-A8704-20UL, ABB-A8704-100UL
• Manufacturer: ABclonal
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, WB
• Species Reactivity: Human
• Immunogen: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
• Conjugation: Unconjugated
• Alternative Names: EPI, TFI, LACI, TFPI1, TFPI

Product Description

This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization.

Product Properties

• Molecular Weight: 35kDa
• NCBI: 7035
• UniProt: P10646
• Purity: Affinity purification
• Target: TFPI

Application Notes

• Application Dilute: WB,1:500 - 1:1000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Application Notes: Cross-Reactivity: Human, ResearchArea: Cardiovascular,Blood.

Images

Western blot analysis of lysates from BxPC-3 cells, using TFPI Rabbit mAb (A8704) at 1:1000 dilution.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 10s.