Phospho-DNMT1-S714 Rabbit pAb, Unconjugated

Produktübersicht

• Artikelname: Phospho-DNMT1-S714 Rabbit pAb, Unconjugated
• Artikelnummer: ABB-AP0021
• Hersteller Artikelnummer: AP0021
• Alternativnummer: ABB-AP0021-20UL, ABB-AP0021-100UL
• Hersteller: ABclonal
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ELISA, IF, WB
• Spezies Reaktivität: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Konjugation: Unconjugated
• Alternative Synonym: AIM, DNMT, MCMT, CXXC9, HSN1E, ADCADN, m.HsaI, Phospho-DNMT1-S714

Produktbeschreibung

This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.

Produkteigenschaften

• Molekulargewicht: 183kDa
• NCBI: 1786
• UniProt: P26358
• Reinheit: Affinity purification
• Target-Kategorie: DNMT1

Anwendungsbeschreibung

• Application Verdünnung: WB,1:500 - 1:2000|IF/ICC,1:50 - 1:200|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Anwendungsbeschreibung: Cross-Reactivity: Human, ResearchArea: Epigenetics Nuclear Signaling,Epigenetic writers and erasers of core Histones,Protein phosphorylation.

Bilder

Immunofluorescence analysis of MCF-7 cells using Phospho-DNMT1-S714 Rabbit pAb (AP0021). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (AS007) at 1:500 dilution. Blue: DAPI for nuclear staining.