Phospho-DNMT1-S714 Rabbit pAb, Unconjugated

Product Overview

• Article Name: Phospho-DNMT1-S714 Rabbit pAb, Unconjugated
• Biozol Catalog Number: ABB-AP0021
• Supplier Catalog Number: AP0021
• Alternative Catalog Number: ABB-AP0021-20UL, ABB-AP0021-100UL
• Manufacturer: ABclonal
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, IF, WB
• Species Reactivity: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Conjugation: Unconjugated
• Alternative Names: AIM, DNMT, MCMT, CXXC9, HSN1E, ADCADN, m.HsaI, Phospho-DNMT1-S714

Product Description

This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.

Product Properties

• Molecular Weight: 183kDa
• NCBI: 1786
• UniProt: P26358
• Purity: Affinity purification
• Target: DNMT1

Application Notes

• Application Dilute: WB,1:500 - 1:2000|IF/ICC,1:50 - 1:200|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Application Notes: Cross-Reactivity: Human, ResearchArea: Epigenetics Nuclear Signaling,Epigenetic writers and erasers of core Histones,Protein phosphorylation.

Images

Immunofluorescence analysis of MCF-7 cells using Phospho-DNMT1-S714 Rabbit pAb (AP0021). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (AS007) at 1:500 dilution. Blue: DAPI for nuclear staining.