Phospho-MDM2-S260 Rabbit pAb, Unconjugated

Produktübersicht

• Artikelname: Phospho-MDM2-S260 Rabbit pAb, Unconjugated
• Artikelnummer: ABB-AP0074
• Hersteller Artikelnummer: AP0074
• Alternativnummer: ABB-AP0074-100UL, ABB-AP0074-20UL
• Hersteller: ABclonal
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ELISA, WB
• Spezies Reaktivität: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Konjugation: Unconjugated
• Alternative Synonym: HDMX, LSKB, hdm2, ACTFS, Phospho-MDM2-S260

Produktbeschreibung

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Produkteigenschaften

• Molekulargewicht: 55kDa
• NCBI: 4193
• UniProt: Q00987
• Reinheit: Affinity purification
• Target-Kategorie: MDM2

Anwendungsbeschreibung

• Application Verdünnung: WB,1:500 - 1:2000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Anwendungsbeschreibung: Cross-Reactivity: Human, ResearchArea: Epigenetics Nuclear Signaling,Protein phosphorylation,Cancer,Tumor suppressors,p53 pathway,Signal Transduction,PI3K-Akt Signaling Pathway,ErbB-HER Signaling Pathway,ATM Signaling Pathway,Cell Biology Developmental Biology,Cell Cycle,Cell cycle inhibitors,Cell Cycle Control-G2 M DNA Damage Checkpoint,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,Immunology Inflammation,Neuroscience.

Bilder

Western blot analysis of lysates from 293 cells, using Phospho-MDM2-S260 Rabbit pAb (AP0074).
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% BSA.