Phospho-ALK-Y1096 Rabbit pAb, Unconjugated

Produktübersicht

• Artikelname: Phospho-ALK-Y1096 Rabbit pAb, Unconjugated
• Artikelnummer: ABB-AP0503
• Hersteller Artikelnummer: AP0503
• Alternativnummer: ABB-AP0503-500UL,ABB-AP0503-100UL,ABB-AP0503-20UL,ABB-AP0503-1000UL
• Hersteller: ABclonal
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ELISA, WB
• Spezies Reaktivität: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Konjugation: Unconjugated
• Alternative Synonym: ALK1, CD246, NBLST3, Phospho-ALK-Y1096

Produktbeschreibung

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).

Produkteigenschaften

• Klonalität: Polyclonal
• Molekulargewicht: 176kDa
• NCBI: 238
• UniProt: Q9UM73
• Reinheit: Affinity purification
• Sequenz: PNYCF
• Target-Kategorie: ALK
• Antibody Type: Primary Antibody

Anwendungsbeschreibung

• Application Verdünnung: WB,1:500 - 1:2000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Anwendungsbeschreibung: Cross-Reactivity: Human, ResearchArea: Protein phosphorylation,Cancer,Signal Transduction,Kinase,Tyrosine kinases,Cell Biology Developmental Biology,Growth factors,Immunology Inflammation,CDs,Neuroscience, Cell Type Marker,Neuron marker.

Bilder

Western blot analysis of lysates from HL-60 and HL-60 cells, using Phospho-ALK-Y1096 Rabbit pAb (AP0503) at 1:1000 dilution. HL-60 cells were treated with 10% FBS after serum-starvation overnight. HL-60 cells were treated with UV for 15-30 minutes.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% BSA.