Phospho-PLC gamma 2 (PLCG2)-Y759 Rabbit pAb, Unconjugated

Produktübersicht

• Artikelname: Phospho-PLC gamma 2 (PLCG2)-Y759 Rabbit pAb, Unconjugated
• Artikelnummer: ABB-AP0785
• Hersteller Artikelnummer: AP0785
• Alternativnummer: ABB-AP0785-20UL,ABB-AP0785-100UL,ABB-AP0785-500UL,ABB-AP0785-1000UL
• Hersteller: ABclonal
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ELISA, WB
• Spezies Reaktivität: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Konjugation: Unconjugated
• Alternative Synonym: FCAS3, APLAID, PLC-IV, PLC-gamma-2, Phospho-PLC gamma 2 (PLCG2)-Y759

Produktbeschreibung

The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3.

Produkteigenschaften

• Klonalität: Polyclonal
• Molekulargewicht: 148kDa
• NCBI: 5336
• UniProt: P16885
• Reinheit: Affinity purification
• Sequenz: RMYVD
• Target-Kategorie: PLCG2
• Antibody Type: Primary Antibody

Anwendungsbeschreibung

• Application Verdünnung: WB,1:500 - 1:2000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Anwendungsbeschreibung: Cross-Reactivity: Human, ResearchArea: Protein phosphorylation,Cancer,Signal Transduction,ErbB-HER Signaling Pathway,MAPK-Erk Signaling Pathway,Cell Biology Developmental Biology,Cytoskeleton,Actins,Endocrine Metabolism,Lipid Metabolism,Immunology Inflammation,B Cell Receptor Signaling Pathway,Cardiovascular,Angiogenesis,Lipids.

Bilder

Western blot analysis of lysates from Raji cells, using Phospho-PLC gamma 2 (PLCG2)-Y759 Rabbit pAb (AP0785) at 1:2000 dilution. Raji cells were treated with Pervanadate (1 mM) at 37°C for 30 minutes.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 1s.