Phospho-DRP1-S616 Rabbit pAb, Unconjugated

Produktübersicht

• Artikelname: Phospho-DRP1-S616 Rabbit pAb, Unconjugated
• Artikelnummer: ABB-AP0849
• Hersteller Artikelnummer: AP0849
• Alternativnummer: ABB-AP0849-1000UL,ABB-AP0849-500UL,ABB-AP0849-20UL,ABB-AP0849-100UL
• Hersteller: ABclonal
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ELISA, WB
• Spezies Reaktivität: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Konjugation: Unconjugated
• Alternative Synonym: DLP1, DRP1, DVLP, EMPF, OPA5, EMPF1, DYMPLE, HDYNIV, Phospho-DRP1-S616

Produktbeschreibung

This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimers disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms.

Produkteigenschaften

• Molekulargewicht: 82 kDa
• NCBI: 10059
• UniProt: O00429
• Reinheit: Affinity purification
• Sequenz: PASPQ
• Target-Kategorie: DNM1L

Anwendungsbeschreibung

• Application Verdünnung: WB,1:500 - 1:5000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Anwendungsbeschreibung: Cross-Reactivity: Human, ResearchArea: Protein phosphorylation,Cancer,Signal Transduction,Cell Biology Developmental Biology,Apoptosis,Endocrine Metabolism,Mitochondrial metabolism,Mitochondrial markers,Neuroscience,Neurodegenerative Diseases,Dopamine Signaling in Parkinsons Disease.

Bilder

Western blot analysis of lysates from HeLa cells, using Phospho-DRP1-S616 Rabbit pAb (AP0849) at 1:1000 dilution. HeLa cells were treated with Calyculin A (100 nM) at 37°C for 30 minutes after serum-starvation overnight.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% BSA.
Detection: ECL Basic Kit (RM00020).
Exposure time: 180s.