Phospho-STING/TMEM173-S366 Rabbit pAb, Unconjugated

Produktübersicht

• Artikelname: Phospho-STING/TMEM173-S366 Rabbit pAb, Unconjugated
• Artikelnummer: ABB-AP1223
• Hersteller Artikelnummer: AP1223
• Alternativnummer: ABB-AP1223-100UL,ABB-AP1223-20UL,ABB-AP1223-500UL,ABB-AP1223-1000UL
• Hersteller: ABclonal
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ELISA, WB
• Spezies Reaktivität: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Konjugation: Unconjugated
• Alternative Synonym: ERIS, MITA, MPYS, SAVI, NET23, STING, hMITA, hSTING, TMEM173, STING-beta, Phospho-STING/TMEM173-S366

Produktbeschreibung

This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.

Produkteigenschaften

• Klonalität: Polyclonal
• Molekulargewicht: 42kDa
• NCBI: 340061
• UniProt: Q86WV6
• Reinheit: Affinity purification
• Sequenz: LISGME
• Target-Kategorie: STING1
• Antibody Type: Primary Antibody

Anwendungsbeschreibung

• Application Verdünnung: WB,1:500 - 1:1000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Anwendungsbeschreibung: Cross-Reactivity: Human, ResearchArea: Epigenetics Nuclear Signaling,Cancer,Immunology Inflammation,Cytokines,Cell Intrinsic Innate Immunity Signaling Pathway.

Bilder

Western blot analysis of lysates from THP-1 cells usingPhospho-STING/TMEM173-S366 Rabbit pAb (AP1223) at1:500 dilution. THP-1 cells were differentiation with TPA (200 nM) for 15 minutes and transfection with poly(dA:dT) (5ug/mL) for 3 hours.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit (RM00021).
Exposure time:30s.