Phospho-STING/TMEM173-S366 Rabbit pAb, Unconjugated

Product Overview

• Article Name: Phospho-STING/TMEM173-S366 Rabbit pAb, Unconjugated
• Biozol Catalog Number: ABB-AP1223
• Supplier Catalog Number: AP1223
• Alternative Catalog Number: ABB-AP1223-100UL,ABB-AP1223-20UL,ABB-AP1223-500UL,ABB-AP1223-1000UL
• Manufacturer: ABclonal
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, WB
• Species Reactivity: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Conjugation: Unconjugated
• Alternative Names: ERIS, MITA, MPYS, SAVI, NET23, STING, hMITA, hSTING, TMEM173, STING-beta, Phospho-STING/TMEM173-S366

Product Description

This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.

Product Properties

• Clonality: Polyclonal
• Molecular Weight: 42kDa
• NCBI: 340061
• UniProt: Q86WV6
• Purity: Affinity purification
• Sequence: LISGME
• Target: STING1
• Antibody Type: Primary Antibody

Application Notes

• Application Dilute: WB,1:500 - 1:1000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Application Notes: Cross-Reactivity: Human, ResearchArea: Epigenetics Nuclear Signaling,Cancer,Immunology Inflammation,Cytokines,Cell Intrinsic Innate Immunity Signaling Pathway.

Images

Western blot analysis of lysates from THP-1 cells usingPhospho-STING/TMEM173-S366 Rabbit pAb (AP1223) at1:500 dilution. THP-1 cells were differentiation with TPA (200 nM) for 15 minutes and transfection with poly(dA:dT) (5ug/mL) for 3 hours.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit (RM00021).
Exposure time:30s.