Phospho-CGAS-S420 Rabbit pAb, Unconjugated

Produktübersicht

• Artikelname: Phospho-CGAS-S420 Rabbit pAb, Unconjugated
• Artikelnummer: ABB-AP1228
• Hersteller Artikelnummer: AP1228
• Alternativnummer: ABB-AP1228-1000UL, ABB-AP1228-20UL, ABB-AP1228-500UL, ABB-AP1228-100UL
• Hersteller: ABclonal
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ELISA, WB
• Spezies Reaktivität: Mouse
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Konjugation: Unconjugated
• Alternative Synonym: Mb21d1, E330016A19Rik, Phospho-CGAS-S420

Produktbeschreibung

The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants.

Produkteigenschaften

• Molekulargewicht: 58kDa
• NCBI: 214763
• UniProt: Q8C6L5
• Reinheit: Affinity purification
• Target-Kategorie: Cgas

Anwendungsbeschreibung

• Application Verdünnung: WB,1:500 - 1:1000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Anwendungsbeschreibung: Cross-Reactivity: Human,Rat

Bilder

Western blot analysis of various lysates using Phospho-CGAS-S420 Rabbit pAb (AP1228) at 1:1000 dilution. 293T and C6 cells were treated with Calyculin A (100 nM) at 37°C for 30 minutes after serum-starvation overnight.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 90s.