Phospho-ATR-S428 Rabbit mAb, Unconjugated

Produktübersicht

• Artikelname: Phospho-ATR-S428 Rabbit mAb, Unconjugated
• Artikelnummer: ABB-AP1358
• Hersteller Artikelnummer: AP1358
• Alternativnummer: ABB-AP1358-100UL,ABB-AP1358-20UL,ABB-AP1358-1000UL,ABB-AP1358-500UL
• Hersteller: ABclonal
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ELISA, WB
• Spezies Reaktivität: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Konjugation: Unconjugated
• Alternative Synonym: FRP1, MEC1, SCKL, FCTCS, SCKL1, Phospho-ATR-S428

Produktbeschreibung

The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [ARC55118]
• Molekulargewicht: 301 kDa
• NCBI: 545
• UniProt: Q13535
• Reinheit: Affinity purification
• Sequenz: GISPK
• Target-Kategorie: ATR
• Antibody Type: Primary Antibody

Anwendungsbeschreibung

• Application Verdünnung: WB,1:500 - 1:2000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Anwendungsbeschreibung: Cross-Reactivity: Human, ResearchArea: Epigenetics Nuclear Signaling,Epigenetic writers and erasers of core Histones,DNA Damage Repair,Protein phosphorylation,Cancer,Tumor suppressors,Signal Transduction,Kinase,Serine threonine kinases,Cell Biology Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,Cell Cycle,Cell Cycle Control-G1 S Checkpoint,Cell Cycle Control-G2 M DNA Damage Checkpoint.

Bilder

Western blot analysis of lysates from 293T cells using Phospho-ATR-S428 Rabbit mAb (AP1358) at1:2000 dilution. 293T cells were treated with UV at room temperature for 15-30 minutes.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 30 µg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 90 s.