Phospho-Cardiac Troponin I (TNNI3)-S23/S24 Rabbit mAb, Unconjugated

Produktübersicht

• Artikelname: Phospho-Cardiac Troponin I (TNNI3)-S23/S24 Rabbit mAb, Unconjugated
• Artikelnummer: ABB-AP1400
• Hersteller Artikelnummer: AP1400
• Alternativnummer: ABB-AP1400-20UL,ABB-AP1400-100UL,ABB-AP1400-500UL,ABB-AP1400-1000UL
• Hersteller: ABclonal
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ELISA, IHC-P
• Spezies Reaktivität: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Konjugation: Unconjugated
• Alternative Synonym: CMH7, RCM1, cTnI, CMD2A, TNNC1, CMD1FF, Phospho-Cardiac Troponin I (TNNI3)-S23/S24

Produktbeschreibung

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit, blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [ARC56024]
• Molekulargewicht: 24kDa
• NCBI: 7137
• UniProt: P19429
• Reinheit: Affinity purification
• Sequenz: RRSSNY
• Target-Kategorie: TNNI3
• Antibody Type: Primary Antibody

Anwendungsbeschreibung

• Application Verdünnung: IHC-P,1:500 - 1:1000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Anwendungsbeschreibung: Cross-Reactivity: Human, ResearchArea: Signal Transduction,Cell Biology Developmental Biology,Cytoskeleton,Microfilaments,Stem Cells,Cardiovascular,Angiogenesis,Heart,Contractility.

Bilder

Immunohistochemistry analysis of paraffin-embedded Human heart using Phospho-Cardiac Troponin I (TNNI3)-S23/S24 Rabbit mAb (AP1400) at dilution of 1:700 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.