Phospho-Cardiac Troponin I (TNNI3)-S23/S24 Rabbit mAb, Unconjugated

Product Overview

• Article Name: Phospho-Cardiac Troponin I (TNNI3)-S23/S24 Rabbit mAb, Unconjugated
• Biozol Catalog Number: ABB-AP1400
• Supplier Catalog Number: AP1400
• Alternative Catalog Number: ABB-AP1400-20UL,ABB-AP1400-100UL,ABB-AP1400-500UL,ABB-AP1400-1000UL
• Manufacturer: ABclonal
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, IHC-P
• Species Reactivity: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Conjugation: Unconjugated
• Alternative Names: CMH7, RCM1, cTnI, CMD2A, TNNC1, CMD1FF, Phospho-Cardiac Troponin I (TNNI3)-S23/S24

Product Description

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit, blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [ARC56024]
• Molecular Weight: 24kDa
• NCBI: 7137
• UniProt: P19429
• Purity: Affinity purification
• Sequence: RRSSNY
• Target: TNNI3
• Antibody Type: Primary Antibody

Application Notes

• Application Dilute: IHC-P,1:500 - 1:1000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Application Notes: Cross-Reactivity: Human, ResearchArea: Signal Transduction,Cell Biology Developmental Biology,Cytoskeleton,Microfilaments,Stem Cells,Cardiovascular,Angiogenesis,Heart,Contractility.

Images

Immunohistochemistry analysis of paraffin-embedded Human heart using Phospho-Cardiac Troponin I (TNNI3)-S23/S24 Rabbit mAb (AP1400) at dilution of 1:700 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.