Polyclonal Antibody to IkB- Alpha (Phospho-Ser32/Ser36), Rabbit

Produktübersicht

• Artikelname: Polyclonal Antibody to IkB- Alpha (Phospho-Ser32/Ser36), Rabbit
• Artikelnummer: ABI-35-1146-50
• Hersteller Artikelnummer: 35-1146-50
• Alternativnummer: ABI-35-1146-50-50UL
• Hersteller: Abeomics
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: IF, IHC, WB
• Spezies Reaktivität: Human, Mouse
• Immunogen: Peptide sequence around phosphorylation site of serine 32/36 (H-D-S(p)-G-L-D-S(p)-M-K) derived from Human IkB-a.
• Alternative Synonym: I-kappa-B-alpha, IKBA, NF-kappaB inhibitor alpha, NF-KBI, NF-KBIA

Produktbeschreibung

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.

Produkteigenschaften

• Klonalität: Polyclonal
• NCBI: 4792
• UniProt: P25963
• Formulierung: Purified
• Target-Kategorie: I?B- Alpha (Phospho-Ser32/Ser36)

Anwendungsbeschreibung

• Application Verdünnung: Predicted MW: 39kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200