Polyclonal Antibody to IkB- Alpha (Phospho-Tyr42) Antibody, Rabbit
Artikelnummer:
ABI-35-1155
Hersteller Artikelnummer:
35-1155
Alternativnummer:
ABI-35-1155-100UL
Hersteller:
Abeomics
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IHC, WB
Spezies Reaktivität:
Human, Mouse
Immunogen:
Peptide sequence around phosphorylation site of tyrosine 42 (E-E-Y(p)-E-Q) derived from Human IkB-a
Alternative Synonym:
IKBA, MAD-3, NF-KBI, NF-KBIA
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.
